Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State
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چکیده
منابع مشابه
Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State
Hox transcription factors (TFs) are essential for vertebrate development, but how these evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofactors, mainly homeodomain TFs Pbx and Meis, to select their specific targets. We mapped binding of Meis, Pbx, and Hoxa2 in the branchial arches, ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2014.12.024